解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The hypothalamic-pituitary-adrenal axis involves timed signaling between the hypothalamus, pituitary, and adrenal glands and back to the brain, causing an inherently oscillating system. Corticosteroids such as corticosterone (CORT) are secreted in a circadian rhythm, characterized by low and high levels at the start o...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00767
更新日期:2019-04-01 00:00:00
abstract::Thyroid hormones regulate bone homeostasis, and exogenously induced hyperthyroidism and hypothyroidism in mice was recently found to be associated with an altered expression of the Wnt inhibitor Dickkopf-1 (Dkk1), a determinant of bone mass. Here, we assessed the role of Dkk1 in thyroid hormone-induced changes in bone...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00998
更新日期:2019-03-01 00:00:00
abstract::The health impacts of endocrine-disrupting chemicals (EDCs) remain debated, and their tissue and molecular targets are poorly understood. In this study, we leveraged systems biology approaches to assess the target tissues, molecular pathways, and gene regulatory networks associated with prenatal exposure to the model ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00817
更新日期:2019-02-01 00:00:00
abstract::17α-Ethinyl estradiol (EE), a synthetic analog of natural estrogen 17β-estradiol (E2), is extensively used in hormonal contraceptives and estrogen replacement therapy, and it has also been found in sewage effluents. Given that E2 is a well-known immunomodulator, surprisingly there has been only limited information on ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00824
更新日期:2019-01-01 00:00:00
abstract::The glucocorticoid (GC) rhythm is entrained to light-dark (LD) cycles via a molecular clock in the suprachiasmatic nucleus (SCN) and is maintained by an adrenal clock synchronized by SCN-dependent signals. Targeted deletion of the core clock gene Bmal1 can disrupt adrenal clock function. The requirement of the adrenal...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00769
更新日期:2018-12-01 00:00:00
abstract::Ca2+ influx through voltage-gated Ca2+ channels (VGCCs) plays a key role in GH secretion. In this review, we summarize the current state of knowledge regarding the physiology and molecular machinery of VGCCs in pituitary somatotrophs. We next discuss the possible involvement of Ca2+ channelopathies in pituitary diseas...
journal_title:Endocrinology
pub_type: 杂志文章,评审
doi:10.1210/en.2018-00743
更新日期:2018-12-01 00:00:00
abstract::Trophoblast hypoxia and injury, key components of placental dysfunction, are associated with fetal growth restriction and other complications of pregnancy. Accumulation of lipid droplets has been found in hypoxic nonplacental cells. Unique to pregnancy, lipid accumulation in the placenta might perturb lipid transport ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00752
更新日期:2018-12-01 00:00:00
abstract::Fundamental complications of insulin resistance and type 2 diabetes include the development of nonalcoholic fatty liver disease and an atherogenic fasting dyslipidemic profile, primarily due to increases in hepatic very-low-density lipoprotein (VLDL) production. Recently, central glucagon-like peptide-2 receptor (GLP2...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00416
更新日期:2018-09-01 00:00:00
abstract::The lateral hypothalamic area (LHA) is essential for motivated ingestive and locomotor behaviors that impact body weight, yet it remains unclear how the neurochemically defined subpopulations of LHA neurons contribute to energy balance. In particular, the role of the large population of LHA neurotensin (Nts) neurons h...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00311
更新日期:2018-09-01 00:00:00
abstract::Early life exposure to endocrine-disrupting chemicals (EDCs) is an emerging risk factor for the development of obesity and diabetes later in life. We previously showed that prenatal exposure to the EDC tributyltin (TBT) results in increased adiposity in the offspring. These effects linger into adulthood and are propag...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00056
更新日期:2018-08-01 00:00:00
abstract::Thyromimetics represent a class of experimental drugs that can stimulate tissue-selective thyroid hormone action. As such, thyromimetics should have effects on the hypothalamic-pituitary-thyroid (HPT) axis, but details of this action and the subsequent effects on systemic thyroid hormone levels have not been reported ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00065
更新日期:2018-07-01 00:00:00
abstract::With the rapid changes in lifestyle in modern society, including the high nutritional intake and reduced physical activity, the incidence of metabolic diseases has been increasing year by year. Obstructive sleep apnea syndrome (OSAS) is a sleep disorder, usually characterized by sudden pauses of breathing during sleep...
journal_title:Endocrinology
pub_type: 杂志文章,评审
doi:10.1210/en.2018-00248
更新日期:2018-07-01 00:00:00
abstract::Chronic exposure to stressors impairs the function of multiple organ systems and has been implicated in increased disease risk. In the rodent, the chronic variable stress (CVS) paradigm has successfully modeled several stress-related illnesses. Despite striking disparities between men and women in the prevalence and e...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00217
更新日期:2018-07-01 00:00:00
abstract::The glycoprotein FSH, a product of pituitary gonadotrope cells, regulates ovarian follicle development in females and spermatogenesis in males. FSH is a heterodimer of the common α gonadotropin subunit and the hormone-specific FSHβ subunit (a product of the Fshb gene). Using a conditional knockout approach (Cre-lox), ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00100
更新日期:2018-07-01 00:00:00
abstract::Adrenocortical carcinoma (ACC) is an aggressive cancer with a 5-year survival rate <35%. Mortality remains high due to lack of targeted therapies. Using bioinformatic analyses, we identified maternal embryonic leucine zipper kinase (MELK) as 4.1-fold overexpressed in ACC compared with normal adrenal samples. High MELK...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00310
更新日期:2018-07-01 00:00:00
abstract::LH supplementation in assisted reproductive technology cycles improves the ongoing pregnancy rate in women with poor ovarian response (POR). However, our knowledge of the precise role of LH during the follicular phase of the menstrual cycle is incomplete. To explore the role of LH in the maturation of small antral fol...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00123
更新日期:2018-06-01 00:00:00
abstract::IGF1-a small, single-chain, secreted peptide in mammals-is essential for normal somatic growth and is involved in a variety of other physiological and pathophysiological processes. IGF1 expression appears to be controlled by several different signaling mechanisms in mammals, with GH playing a key role by activating an...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00259
更新日期:2018-06-01 00:00:00
abstract::Luteinizing hormone/chorionic gonadotropin receptor (LHR) expression in the ovary is regulated by a messenger RNA (mRNA) binding protein, which specifically binds to the coding region of LHR mRNA. We have shown that miR-122, a short noncoding RNA, mediates LHR mRNA levels by modulating the expression of LHR mRNA-bindi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-03270
更新日期:2018-05-01 00:00:00
abstract::Estrogens bind to two nuclear estrogen receptor (ER) subtypes, ERα and ERβ, which are expressed in differing amounts in various tissues. The endogenous estrogen, 17β-estradiol (E2), binds to both subtypes with nearly equal affinity and is the prototypical agonist. Selective estrogen receptor modulators (SERMs) may bin...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00081
更新日期:2018-05-01 00:00:00
abstract::Fibroblast growth factor (FGF) 21, a unique, largely liver-derived endocrine member of the FGF superfamily, is often thought of as a fasting factor owing to its induction in rodents during starvation. However, FGF21 is not increased by fasting for periods of <7 days in humans; instead, it rises sharply after acute alc...
journal_title:Endocrinology
pub_type: 杂志文章,评审
doi:10.1210/en.2018-00208
更新日期:2018-05-01 00:00:00
abstract::Hypoxia plays a vital role in the progression of endometriosis. Additionally, integrin-mediated aberrant adhesion is also essential for establishment of endometriotic lesions. In this study, we sought to determine the function of hypoxia in integrin-mediated adhesion of endometrial stromal cells (ESCs) in endometriosi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-03227
更新日期:2018-04-01 00:00:00
abstract::Cripto-1 (TDGF1) is a multifunctional signaling factor that stimulates cellular effects, including proliferation, migration, survival, epithelial-to-mesenchymal transition, and angiogenesis, to regulate embryogenesis, tissue homeostasis, and tumorigenesis. Those cell behaviors are also associated with implantation of ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-03039
更新日期:2018-04-01 00:00:00
abstract::Pituitary growth hormone (GH) and insulinlike growth factor (IGF)-1 are anabolic hormones whose physiological roles are particularly important during development. The activity of the GH/IGF-1 axis is controlled by complex neuroendocrine systems including two hypothalamic neuropeptides, GH-releasing hormone (GHRH) and ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-03175
更新日期:2018-04-01 00:00:00
abstract::Prenatal dexamethasone exposure (PDE) induces multiorgan developmental toxicities in offspring. Here we verified the transgenerational inheritance effect of ovarian developmental toxicity by PDE and explored its intrauterine programming mechanism. Pregnant rats subcutaneously received 0.2 mg/kg/d dexamethasone from ge...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00044
更新日期:2018-03-01 00:00:00
abstract::In the adrenal gland, neuroendocrine cells that synthesize catecholamines and epithelial cells that produce steroid hormones are united beneath a common organ capsule to function as a single stress-responsive organ. The functional anatomy of the steroid hormone-producing adrenal cortex and the catecholamine-producing ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00064
更新日期:2018-03-01 00:00:00
abstract::Retinoid X receptor (RXR) occupies a central position within the nuclear receptor superfamily, serving as an obligatory partner to numerous other nuclear receptors, including vitamin D receptor (VDR). In the current study, we examined whether phosphorylation of RXRα at serine 260 affects VDR/RXR and VDR interacting pr...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-03098
更新日期:2018-03-01 00:00:00
abstract::Insulin coordinates the complex response to feeding, affecting numerous metabolic and hormonal pathways. Forkhead box protein O1 (FoxO1) is one of several signaling molecules downstream of insulin; FoxO1 drives gluconeogenesis and is suppressed by insulin. To determine the role of FoxO1 in mediating other actions of i...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00870
更新日期:2018-03-01 00:00:00
abstract::The contributions of estradiol and testosterone to atherosclerotic lesion progression are not entirely understood. Cross-sex hormone therapy (XHT) for transgender individuals dramatically alters estrogen and testosterone levels and consequently could have widespread consequences for cardiovascular health. Yet, no prec...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00884
更新日期:2018-02-01 00:00:00
abstract::Angiotensin II receptors regulate muscle microvascular recruitment and the delivery of nutrients, oxygen, and insulin to muscle. Although angiotensin type 1 receptor antagonism increases muscle microvascular perfusion and insulin action, angiotensin type 2 receptor blockade markedly restricts muscle microvascular bloo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00585
更新日期:2018-02-01 00:00:00
abstract::The central characteristic of uterine fibroids is excessive deposition of extracellular matrix (ECM), which contributes to fibroid growth and bulk-type symptoms. Despite this, very little is known about patterns of ECM protein expression in fibroids and whether these are influenced by the most common genetic anomalies...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-03018
更新日期:2018-02-01 00:00:00
abstract::α7-Nicotinic acetylcholine receptor (α7nAChR) agonists confer protection against a wide variety of cytotoxic insults and suppress oxidative stress and apoptosis in various cell systems, including hepatocytes. We recently demonstrated that nicotine, when combined with a high-fat diet (HFD), triggers oxidative stress, a...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00594
更新日期:2018-02-01 00:00:00
abstract::The atrophy and hypofunction of the adrenal cortex following long-term pharmacologic glucocorticoid therapy is a major health problem necessitating chronic glucocorticoid replacement that often prolongs the ultimate return of endogenous adrenocortical function. Underlying this functional recovery is anatomic regenerat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-03061
更新日期:2018-02-01 00:00:00
abstract::Contrary to widespread belief, the implantation of an embryo for the initiation of pregnancy is like a battle, in that the embryo uses a variety of coercive tactics to force its acceptance by the endometrium. We propose that embryo implantation involves a three-step process: (1) identification of a receptive endometri...
journal_title:Endocrinology
pub_type: 杂志文章,评审
doi:10.1210/en.2017-03082
更新日期:2018-02-01 00:00:00
abstract::Androgen signaling in prostate smooth muscle cells (pSMCs) is critical for the maintenance of prostate homeostasis, the alterations of which are a central aspect in the development of pathological conditions. Testosterone can act through the classic androgen receptor (AR) in the cytoplasm, eliciting genomic signaling,...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00718
更新日期:2018-02-01 00:00:00
abstract::A major cause of infertility in normal and assisted reproduction cycles is failure of the endometrium to undergo appropriate changes during the secretory phase of the menstrual cycle as it acquires receptivity for an implanting blastocyst. Current dogma states that loss of epithelial polarity in the luminal epithelial...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1877
更新日期:2018-01-01 00:00:00
abstract::It is assumed that after complete bilateral adrenalectomy (ADX), no adrenal tissue will redevelop and adrenal hormone levels will remain low and unaffected by stress. However, anecdotal observations in animals and in patients suggest that under some unknown circumstances the opposite can occur. Herein, we studied whet...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00505
更新日期:2018-01-01 00:00:00
abstract::Wnt-initiated signaling through a frizzled receptor and the low-density lipoprotein-related receptor-5 coreceptor instructs key anabolic events during skeletal development, homeostasis, and repair. Recent studies indicate that Wnt signaling also regulates the intermediary metabolism of osteoblastic cells, inducing glu...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00850
更新日期:2018-01-01 00:00:00
abstract::Increased toxicant exposure and resultant environmentally induced diseases are a tradeoff of industrial productivity. Dioxin [2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD)], a ubiquitous byproduct, is associated with a spectrum of diseases including endometriosis, a common, chronic disease in women. TCDD activates cytoch...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00860
更新日期:2018-01-01 00:00:00
abstract::Primary aldosteronism (PA) is a common form of endocrine hypertension that is characterized by the excessive production of aldosterone relative to suppressed plasma renin levels. PA is usually caused by either a unilateral aldosterone-producing adenoma or bilateral adrenal hyperplasia. Somatic mutations have been iden...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00637
更新日期:2017-12-01 00:00:00
abstract::Inflammation can interfere with endometrial receptivity. We examined how interleukin 1β (IL-1β) affects expression of the uterine gap junction protein connexin 43 (Cx43), which is known to be critical for embryonic implantation. We used an in vitro model of human endometrial stromal cells (ESCs), Western blotting, and...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00495
更新日期:2017-12-01 00:00:00